@misseschris 2104 wrote:

I am wondering if anyone knows anything about vitamin D3 and hives? I have slowly worked my way up to 5000iu D3 over the past 3 months. I take cofactors as well, such as vitamin A, K complex and a small amount of calcium (I’ve taken magnesium for quite some time- adding the calcium only recently as I do eat dairy). I had a low test result even though I live in California. I also have hypothyroidism which is probably why my levels are low. Over the past few days I have developed hives, and am wondering if this could be the result of the vitamin D? I haven’t eaten anything unusual or taken any new supplements. I do have Hashimoto’s and have had small outbreaks of hives over the past 6 months or so- but this is much more severe.
???

Signals and substances have positive and negative actions depending on many factors including concentration, duration of action, delivery path, etc.

For example, Estradiol has many positive qualities. It can stimulate libido in women, promote bone growth, muscle growth, have antidepressant properties, promotes competitiveness and drive, promotes energy, can promote neuron growth and connections, etc. However, estradiol given orally can also increase pro-inflammatory signaling significantly, causing numerous problems.

Vitamin D has many positive qualities. It has anti-inflammatory activity – via anti-oxidant activity, promoting serotonin and dopamine signaling, and reducing insulin resistance. However, it can also have pro-inflammatory. When given in high oral concentrations, it can overstimulate the immune system. Thus, when a person already has significant problems with an overactive immune system, oral vitamin D can promote inflammatory conditions – such as hives. This increase in immune system activity may also active sympathetic nervous system activity, leading to an increase in stress, anxiety, irritability, etc. etc. This may overwhelm the anti-inflammatory and calming effects of Vitamin D, depending on the individual.

These days, I prefer having patients obtain vitamin D the natural way by having more animal fat in their diets. This introduces Vitamin D into the body in a slower and less concentrated manner. In traditional nutrient dense diets, the Vitamin D content can be 10 times that of a modern diet. Thus, supplementation may not be necessary when nutrition is optimized. This would then emphasize vitamin D’s anti-inflammatory effects rather than the pro-inflammatory effects.

@keithdolby 2245 wrote:

Dr. M, In your 2nd paragraph you mentioned that estradiol increases bone growth. I have always read that estradiol is a main reason why the average female is shorter than the average male. Just becasue the average female develops faster than males and reaches their full height quicker, dosent really mean estradiol increases bone growth? Confussed about this statement b/c I always thought estradiol helped stop bone growth.

Estradiol is important for bone formation. It helps bone become denser. Without adequate amounts, one can develop osteoporosis. (This is what I am referring to when I say bone growth – which in retrospect was probably too vague a term, thus your confusion).

Lengthening of the bones – which leads to growth in stature – is determined by the growth plates. This is a thin layer of cells at the ends of the bone. The growth plate dies off when the concentration of reproductive hormones (testosterone or estrogen) becomes high enough (such as when the ovaries or testes become fully mature and functional). Since the ovaries mature earlier than the testes, females tend to be shorter than men.

Since the birth of my daughter my skin condition grew worse for the last 5 years is …
It’s like my body is attacking my skin …
My body already attacked my hair I have absolutly no …
I have tested allergic … the dermatologist skin biopsy, but they say it is exema …
My bed all night because I .. ‘m scratching looks like a murder scene
I have been on prednizone, allergy pills .. Anit depressants and now is trying but I can tell that’s not going to work …