I think GABA balances out the high NE. Try taking some GABA. I have tried it, but I didn’t notice much difference. There are different opinions on the doses of GABA and if it really crossed the brain barrier too, but give it a try.

@loopy107 2075 wrote:

I’m asking this because I’ve have symtoms of higher Norepinephrine than dopamine. I have suffered from serious premature ejaculation all my life. I’m talking ejaculation as I would begin intercourse. If I’m lucky than I can last 10 seconds tops on a good day. I constantly keep hearing ringing in my ears from morning unitl I go to sleep everyday which I’ve heard can be from high Norepinephrine. I’ve had add symptoms for many years and tried few drugs like adderall, concerta, and wellbutrin.

Adderall and concerta make me feel high. Adderall burns be out badly the next morning too.

Wellbutrin actually improved my mood, and had increased my libido too, but at certain doses made my ears ring badly (400mg per day). Did improve my focus without making me feel high. At 400mg I did get anxiety attacks.

I am on trt, thyroid meds, and HC tabs. I just need a kick in dopamine with some medication but not sure what. For some reason wellbutrin help my premature ejaculation a bit. I would last 30 seconds which is still misserable but improvement at that time.

Not sure what to try but need to fix premature ejaculation issue as well. I know that I need dopanmine for a kick in libido since it is low.

Anyone have experiance with anything that works but doesn’t make you feel high?
Could the reason my dopamine is low is because my Norepinephrine is too high?

How would I fix that?

Dopamine and norepinephrine are signals given out by different groups of cells in the nervous system. Norepinephrine is made from Dopamine. Dopamine released from norepinephrine-releasing cells is primarily leakage in the production line for creating norepinephrine.

Dopamine and Norepinephrine each have multiple functions, some of which overlap and may oppose each other. For example, norepinephrine promotes alertness. But too much dopamine can make one very sleepy. Dopamine promotes attention. But it has to work in conjunction with norepinephrine in allowing a person to be alert and attentive. Dopamine helps reduce norepinephrine signaling. Producing norepinephrine may lead to a reduction in dopamine production since continuing dopamine signaling may be counterproductive to the production of norepinephrine. Dopamine is one of the primary signals, if not the primary signal, for libido. But it needs to work with norepinephrine so one can get excitement from sex. Norepinephrine is the signal that triggers the orgasm. Excessive norepinephrine can reduce libido. This may occur through multiple signaling pathways. For example, dopamine production can be reduced. Immune system signaling may be increased – triggering defensive behavioral programs which turn off libido. Thus, even if dopamine signaling is sufficient, if the immune system shuts down libido, one won’t have it.

The actual question to ask is “Why is norepinephrine high?” There are many reasons it may be high. One of the primary ones is that there is something wrong in the body – such as an infection or other stress. The immune system, in this case, may trigger higher norepinephrine production to signal the rest of the body that there is a serious problem to address. Norepinephrine is the signal for distress or something going wrong. A second reason is that norepinephrine is also a signal for generating energy. If there is a deficit in energy production from the other signaling and metabolic pathways, then an increase in norepinephrine may be necessary to compensate for the deficit in energy production. Etc. Etc.

Why may dopamine be low? There are numerous reasons. One can have a biological predisposition for low dopamine production (e.g. those at risk for Parkinson’s disease). Norepinephrine signaling may be high. Immune system pro-inflammatory cytokine signaling may be high. Thyroid signaling may be suboptimal. Adrenal signaling may be suppressed. Testosterone signaling may be low. Estradiol signaling may be low. Metabolically, there may be deficits in Vitamin D and iron, which impairs dopamine production. Etc. etc.

A “high” usually means increasing dopamine and norepinephrine in tandem to produce an elevated mood.

Bupropion (Wellbutrin), particularly at high doses, tends to primarily raise norepinephrine, not dopamine.

Dopamine agonists are an option for some for increasing libido if the optimization of other signaling systems does not work sufficiently. It doesn’t work fully well in most, though it some it works very well. Without norepinephrine this usually doesn’t lead to a high. Abnormal muscle movements, heart valvular disease, drop attacks of sleep, etc. are some of the concerns with long-term use.