I assume the main mediators of metabolism are thyroid hormones and cortisol and optimal levels of each would create a fast metabolism.

Does low cortisol slow metabolism?

Or is it simply because thyroid cannot uptake into the cells?

To what extent are other hormones involved? renin, aldosterone, testosterone, DHEA’s?

I know HAN mentioned he had bodybuilders who he was taking care of eating 5000 calories a day while “dieting” while others where starving themselves.

So HAN can you give us your expert advice how do you create a ectomorph like metabolism?