@pmgamer18 886 wrote:

My wife was on HRT for a time some yrs. ago until the big breast cancer scare come out then she stopped it. Three yrs ago she has Knee replacement sugary and after this she can’t sleep and lost her libido. I have been on TRT or Testosterone meds for 27 yrs. I know lot about them and help men on the forums with this problem.

But when it comes down to women and there hormones I am lost. Yet I get a lot of women posting to me about it.

My wife seen her Dr. for a scan on her privet parts she thought she found a lump. My wife told her that the Ambien she tried to help her sleep did not work so her Dr. talked her into going back on HRT. I have been telling her to do this for yrs. but she kept telling me they cause cancer. I told her she can get natural hormones or what they call Bio identical Hormones.

I am not sure if what she is on is safe here is what the Dr. gave her.
Provera/Medroxprogesterone Aceta 1 x’s/day 2.5 mgs. and Estrace/Gynodiol/Estradiol 1 x’s/day .5 mgs.

She has been on this 5 days now and says she is sleeping a little better dose not need Xanax anymore.

Dr. M or anyone I need help on this one.

Provera/Medroxprogesterone Aceta 1 x’s/day 2.5 mgs. and Estrace/Gynodiol/Estradiol 1 x’s/day .5 mgs.

These are a diaster waiting to happen. With females hormones these are not true progesterone and when tested in urine or saliva will reveal a low progesterone levels.
If she was under Dr O he would switch her to bi-est, with natural progesterone.
These drugs are why progesterone are known to cause increase in breast cancer and other health risk. I would look for Dr that specializes in bioidentical hormones in your area. Dr john now does wonem hormones or has dr’s that do. If they are any good or not I would not know. In our practice a lot of the symptoms your wife has clears up with in the first week on progesterone. If she has problem sleeping them lozengers and potential combination of gels of both would be the best remedy. In TRT our concern is saftey and her current regime she is on is putting her at high risk. From research that i have done. Progesterone deficiency comes from years of cortisol demand which eventually depletes progesterone. Since you are in the goiter belt I would have her also on iodoral to help regulate estrogen metabolism as a safety valve for the HRT. By regulating her progesterone/e2 ratio with bioidentical hormones her thyroid medications may need to be altered as well as the metabolic shift from estrodial to progesterone on the receptors.

@pmgamer18 886 wrote:

My wife was on HRT for a time some yrs. ago until the big breast cancer scare come out then she stopped it. Three yrs ago she has Knee replacement sugary and after this she can’t sleep and lost her libido. I have been on TRT or Testosterone meds for 27 yrs. I know lot about them and help men on the forums with this problem.

But when it comes down to women and there hormones I am lost. Yet I get a lot of women posting to me about it.

My wife seen her Dr. for a scan on her privet parts she thought she found a lump. My wife told her that the Ambien she tried to help her sleep did not work so her Dr. talked her into going back on HRT. I have been telling her to do this for yrs. but she kept telling me they cause cancer. I told her she can get natural hormones or what they call Bio identical Hormones.

I am not sure if what she is on is safe here is what the Dr. gave her.
Provera/Medroxprogesterone Aceta 1 x’s/day 2.5 mgs. and Estrace/Gynodiol/Estradiol 1 x’s/day .5 mgs.

She has been on this 5 days now and says she is sleeping a little better dose not need Xanax anymore.

Dr. M or anyone I need help on this one.

The question is: how does one keep hormone replacement therapy safe?

There is some risk of breast cancer with Estrogens and Progesterone.

There is a significant risk of blood clots and heart problems with the use of Progestins ( artificial progesterones ).

Thus, how does one keep safe? How does one lower the risk?

When it comes to the risk of heart attacks and blood clots, clearly (particularly since Provera + Estradiol = PremPro), the World Health Organization’s study showed the use of Provera increased the risk for both problems.

As a result of this study, I prefer Estradiol alone to Estradiol + Provera.

I prefer Estrogen and Progesterone to Estradiol alone for the health benefits and to reduce the risk of using Estradiol alone.

And I prefer Estradiol + Estriol to Estradiol or Premarin when it comes to choosing an Estrogen.

When it comes to reproductive system cancers, such as breast cancer, there are ways to reduce the risk.

Three modifiable factors which may reduce the risk for breast cancer while on hormone replacement therapy are:

1. Adequate Iodine intake
2. Adequate Vitamin D intake.
3. Using Estradiol with Estriol (Bi-Est)

A good reference to iodine is Dr. Browntein’s excellent book on iodine: Iodine – Why you need it. http://www.drbrownstein.com/

Even if a woman is not on hormone replacement therapy, when iodine and vitamin D are both low, the risk of developing breast cancer is significantly higher than with adequate levels of both.

When it comes to adequate iodine levels, I agree with Dr. Brownstein, though I don’t advocate using 50 mg of iodine a day all the time.

What is Bi-Est?
Bi-Est is short for Bi-Estrogen.
The two estrogens are Estradiol and Estriol.
The woman’s body has three estrogens:
Estrone (E1), Estradiol (E2), Estriol (E3).
====================================
collegepharmacy

Triest

Triest is a combination of three estrogens: estriol, estradiol and estrone.
It is most commonly found in a ratio of 80:10:10, estriol, estradiol, and estrone.
This combination is very popular and contains all of the three major circulating estrogens.
It may be slightly weaker in its effect when compared to biest.
However, this may be compensated for by increasing the strength or by slightly changing the ratios

…..

@DrMariano 920 wrote:

Bi-Est is 80% Estradiol + 20% Estriol.

I prefer using it to Tri-Est, which contains Estrone. Estrone tends to give a higher risk for breast cancer.

How do you figure correct dose?
I would think:

First 20 days, Quest Diagnostics
Estrogens, Fractionated, LC/MS/MS (36742X)

Estrone, serum
Estradiol, serum
Estriol

or urine from Rhein or Meridian

Quest tests are paid by insurance,
Rhein or Meridian direct cash but give 2, 4, 16 and other information.

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