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For me it was getting my Estradiol levels down when I first tested I was above 90 I took Arimidex .5 mgs everyday and it come down to 24 my Free T levels shot up to above the top of the range and my SHBG came way down to 20. The thing about doing that much arimidex is you can go to low this happened to me. I had to stop taking it for 6 weeks I did not know I was to low for over 8 weeks.
Today I gage my Estradiol levels by how I feel and my involuntary nocturnal erections that appear during REM (Rapid Eye Movement) sleep. When my Estradiol levels go to low I lose my nocturnal erections so I stop taking my Arimidex until they come back takes about 3 to 4 days if you catch this fast. The day they come back I go back on arimidex but take less of it. So between the nocturnal erections and labs I do good. Today I do about .25mgs of Arimidex or 1/4 of a 1 mg. pill every 2 to 3 days.
I find Estradiol changes from month to month some times week to week and I need to adjust my arimidex dose to keep my levels in the sweet spot. Today I am doing .25 mgs everyday.
I keep a log on what I am taking and how I am feeling in time one can get very good at telling if they are going to low or to high. If you don’t have involuntary nocturnal erections that appear during REM (Rapid Eye Movement) sleep them your Estradiol levels just might be to high and this keep SHBG high this is what binds up Testosterone.
I have told so many men about this that were on TRT and suffered from ED and they found getting there hormones leveled and keeping there Estradiol down to about 20 pg/ml they got there sex life back.
@BlackJack 358 wrote:how does one lower SHBG and therefore increase Free / BA testosterone?
I respect what Phil is doing for himself.
However, I generally want to maintain SHBG (sex-hormone binding globulin) since it prolongs the duration of action of testosterone. Most of the time, I find SHBG too low rather than too high.
Testosterone, itself, will drive SHBG down.
Estrogen will increase SHBG. Thus controlling estradiol will lower SHBG.
Insulin also will drive SHBG down. Insulin has the strongest effect on SHBG, compared to any other factor.
Low SHBG is a good sign that a person has insulin resistance or diabetes – with lowers testosterone production. Insulin resistance or diabetes greatly increases the risk for cardiovascular disease.
@BlackJack 391 wrote:
Dr. M from your experience where do you usually like to see SHBG ?
The amount of SHBG that does not indicate pre-diabetes or diabetes (i.e. a low level).
Realize that SHBG is determined by multiple hormones: Estrogen, Progesterone, Thyroid hormone, Testosterone, DHEA, Growth Hormone, Insulin, etc.
Thus, whatever SHBG one has – outside of a low level, for which problems with insulin need to be assess, does not tell if something is wrong since the effects of these hormones may cancel each other out.
Thus, a specific SHBG, outside of diabetes, does not tell much about what is happening with a person.
I generally do not like driving SHBG too low since testosterone and estrogen won’t last long in the body.
@BlackJack 422 wrote:
Could Iodoral increase SHBG in some individuals?
I haven’t seen an effect of iodine on SHBG, in a person who has doesn’t have goiter or frank iodine deficiency.
The lower the shbg the more likely the testosterone is to linker around the body vs higher shbg would tend to burn up faster.
@hardasnails1973 426 wrote:
The lower the shbg the more likely the testosterone is to linker around the body vs higher shbg would tend to burn up faster.
The lower the SHBG, the more likely testosterone level is going to be low since free testosterone has a half-life of only 10 to 100 minutes.
Without SHBG, nearly all testosterone (unless it is continuously produced) would be gone from the body in less than about 50 minutes to 8 hours, being destroyed by degradative enzymes, such as by those in the liver.
SHBG makes testosterone last longer.
The higher the SHBG, the lower the dose of testosterone is needed in treatment.
Insulin, by reducing SHBG, contributes to hypogonadism in diabetes.
That is extremely interesting because every one has been concerned about lower shbg to help increase bio T, but the lower the shbg the faster more frequent one will need T. So these people with lower shbg will result better more frequent shots. Higher the SHBG the more likely testosterone lingers around and is usable to the body. If that is true then higher shbg would be more likely to be more anabolic then having lower shbg. Please correct me if I am wrong in my thinking. To summerize higher shbg the more the testosterone functions in the body. The lower shbg the more the body will burn it up. Does this also imply to estrodial as well?
I am confused because I am told that my high SHBG is NOT good either. Is Dr. M saying anything not considered low is okay? Mine hovers in the mid to high 60’s (nmol/L). What I did notice is when I took Danazol to drive it down my Total T went way down as well. When I got SHBG down 50% to around 30 nmol/L my Total T went down 65% to around 400 ng/dL. Why is that? Also, I have high Antibodies and am told I have Hashis. Therefore, is it possible that the antibodies are attaching the thyroid, causing it to produce too much hormone? My free T3 # on my last test was close to the bottom of the range. I am not taking any supplements.
@hardasnails1973 451 wrote:
That is extremely interesting because every one has been concerned about lower shbg to help increase bio T, but the lower the shbg the faster more frequent one will need T. So these people with lower shbg will result better more frequent shots. Higher the SHBG the more likely testosterone lingers around and is usable to the body. If that is true then higher shbg would be more likely to be more anabolic then having lower shbg. Please correct me if I am wrong in my thinking. To summerize higher shbg the more the testosterone functions in the body. The lower shbg the more the body will burn it up. Does this also imply to estrodial as well?
I am wondering if there is a such a thing as testosterone antibodies. I talked to the head director of quest nichols institute and he told me there is an actual test for that. I have never heard of it. There is actually a study saying that thyroid hormone t-3 mainly can cause an increase in SHBG over time. I will see if I can find it. Are you on thyroid meds at all? Gh deficiency can also cause it to increase as well. Have you had this ruled out?
No, I am not on anything right now. I was on Armour but the DO refused to treat my adrenals first. When I did the 4xcortisol/DHEA test I was low all day….10 (13-24) in the morning, dont have the #s in front of me but low the next two times as well. The 10 pm I was 1 (1-4) so I was in range. DHEA = 2 on (3-10). Cant remember cortisol burden but it was below the bottom. I showed her this info. but all she gave me was a product she sold. Even at 1/2 grain of Armour I started getting anxiety…but it was really strange. I was anxious and tired at the same time. Needless to say I stopped it. Now I dont take anything. I am supposed to have a consult with a doctor soon but for one reason or another it keeps getting pushed back. Unfortunately, I have already paid him. I think I talked to you about it. I was flying up on a Thursday, got a call five days before from his secretary telling me he would be out of town and I needed to reschedule. Due to conflicts I couldnt. Lost almost all the money I paid on the flight, hotel and car. Wasnt happy.
@hardasnails1973 454 wrote:
I am wondering if there is a such a thing as testosterone antibodies. I talked to the head director of quest nichols institute and he told me there is an actual test for that. I have never heard of it. There is actually a study saying that thyroid hormone t-3 mainly can cause an increase in SHBG over time. I will see if I can find it. Are you on thyroid meds at all? Gh deficiency can also cause it to increase as well. Have you had this ruled out?
The doctor is very busy man with now running 2 office, giving seminars, flying all over the country at first notice. Again I am medical professional when people ask my opinon about other Dr’s I tell them go see for your self. One thing I will not do is talk bad about other medical professional. I am not a Dr and will not place judgement upon their mode of practice. When I go to seminars with my Dr I just keep my mouth shut until the end when it is time to ask questions then I will make my presence known. The number one rule to success is keeping the clients happy. Remember the patient is paying you to find out about them not to sit and listen to what the dr accomplished for 3/4 of the time. I have spent 1200 bucks between the test and the consultation to end up listening to her talk about her accomplishments, how she won this award, traveled to europe, BLAH BLAH. I almost walked out of her office but I needed the long waited test results I had been waiting for 3 months to get because she was out of the country. We spent a whole 15 minutes going over them that was it !!. Just be patient he will get back to you. I hate waiting as well so I understand completely because you are probably pulling your hair out waiting. In the past 4-5 years i blew over 50,000 on Dr’s and supplements. One treatment was $15,000 for 8 weeks.
yes, I had low SHBG and 1x per week test cyp injections left me with bad anxiety mid week as my hormones would come crashing down. It was like PMS every week. I needed 2x per week until I got my Thyroid, Adrenals etc straightened out.
Low SHBG usually causes emotional issues or at least is concurrent with it.
@hardasnails1973 451 wrote:
That is extremely interesting because every one has been concerned about lower shbg to help increase bio T, but the lower the shbg the faster more frequent one will need T. So these people with lower shbg will result better more frequent shots. Higher the SHBG the more likely testosterone lingers around and is usable to the body. If that is true then higher shbg would be more likely to be more anabolic then having lower shbg. Please correct me if I am wrong in my thinking. To summerize higher shbg the more the testosterone functions in the body. The lower shbg the more the body will burn it up. Does this also imply to estrodial as well?
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