@DrMariano 483 wrote:

As far as I know, Dihydrotestosterone (DHT) when too high poses some problems:

male pattern hair loss in men with high scalp 5-alpha reductase levels
excessive body hair
acne

Isn’t there a relationship between high DHT retroperitoneal fat and a relationship to insulin (perhaps increased IR risk ?) ? Off the top of my head, I seem to remember reading about this. I also read an article by Patrick Arnold last year where he wrote that in muscle tissue, DHT isn’t involved or is marginelly active, whereas as an androgen DHT has much to do in CNS signaling. Furthermore, I seem to remember that testosterone isn’t very much active in CNS signaling but is very much in muscle tissue.

My DHT has been consistently elevated, and I have vertex MPB to show for it. Very little acne in my back, none on my chest, and zero on facial skin. As a teen however, I had a severe case of cystic acne (back, face, chest) from age 14 up until 24 years old. It was tough seeing my peers hanging out with girls, while I had to keep to myself.

@Shaolin 495 wrote:

Systemic dht doenst have any value and it does certainly not mean that you will find the same amounts regionally, for example in your hypothalamus, your prostate, your skin or wherever you are referring to. Measuring DhT in blood is by far useless, unless we are talking about extremely low levels (like in androgen insensitivity after GnRH stimulation) or extremely high – dont know of any such syndrome !! In functional situations, it doesnt have any use though. If you could cut out your prostate or pituitary and measure the dht levels there then that would really be usefull. Very complicated hormone metabolite to discuss about.

Why do you mention you have some partial insensitivity though, i don understand that?? How did you find out about this???

Partial insensitivity ?

In my case, my serum DHT is consistently elevated to downright off the chart. I have vertex MPB, denoting I have elevated SRD5A1 activity in my scalp.

What I made reference to is that I seem to recall having seen a relationship between high DHT and insulin resistance and increased retroperitoneal fat deposition.

@Jean 510 wrote:

I have high DHT level with testo gel without hair loss (I have plenty of hair), no acne at all, no high skin oil, no high PSA !!!
my libido is fine too

You probably do not have the genetic makeup for MPB, as it seems to have much to do with genetics, even though DHT has been pointed out as one of the major culprit. Scalp 5ar type 1 is most likely determined by the MPB gene.

@chipdouglas 484 wrote:

Isn’t there a relationship between high DHT retroperitoneal fat and a relationship to insulin (perhaps increased IR risk ?) ? Off the top of my head, I seem to remember reading about this. I also read an article by Patrick Arnold last year where he wrote that in muscle tissue, DHT isn’t involved or is marginelly active, whereas as an androgen DHT has much to do in CNS signaling. Furthermore, I seem to remember that testosterone isn’t very much active in CNS signaling but is very much in muscle tissue.

My DHT has been consistently elevated, and I have vertex MPB to show for it. Very little acne in my back, none on my chest, and zero on facial skin. As a teen however, I had a severe case of cystic acne (back, face, chest) from age 14 up until 24 years old. It was tough seeing my peers hanging out with girls, while I had to keep to myself.

From the more recent studies I’ve seen, DHT helps reduce visceral fat (belly fat) and reduces insulin resistance.

Testosterone can be considered a precursor for DHT in the brain. But both testosterone and DHT can act on testosterone receptors.

In muscles, DHT does not signal for muscle hypertrophy. Testosterone signals for muscle hypertrophy.

DHT in the body helps determine secondary male characteristics including body hair.