@BlackJack 155 wrote:

Whats the best way to lower norepinephrine?
increasing Ferritin?
on my last Neurotransmitter test, i tested high for this

First, Ferritin:

Increased iron intake would be necessary to increase Ferritin.

There is no “best way”. It has to be customized to the person.

Medically, this can be done by treatment with Ferrous Sulfate, which gives close to 50 mg per 325 mg tablet. There are other forms, such as Ferrous Gluconate, which are easier on the stomach.

Via supplements, there are over-the-counter Iron supplements. Iron is also a component of multivitamins with minerals.

Via foods, eating red meat would give the greatest amount of iron per serving.

Vitamin C and sugars would increase iron absorption.

Regarding Norepinephrine:

There is no best way either to lower norepinephrine. Treatment has to be tailored for the person.

Norepinephrine is:
1. a signal for stress – e.g. environmental, life stresses, infection, injury, etc.
2. a signal for wakefulness and alertness
3. a signal for energy on demand
4. a signal to maintain blood pressure
5. a signal to generate heat to maintain body temperature.
6. a signal to trigger an orgasm
7. a signal to clear the lungs so one can breath
8. a signal to active the immune system
9. etc. etc.

Thus, when norepinephrine is high, it is important to find out why it is high, then address those reasons first before directly shutting it down.

For example, if one is low on thyroid hormone or iron, norepinephrine increases to compensate for the impaired energy production that occurs.

If there is impaired control over norepinephrine – such as in impaired production of cortisol, testosterone, estradiol, progesterone, serotonin, dopamine, etc. – then norepinephrine goes up.

If there is diabetes, norepinephrine goes up.

If there are clogged arteries to the brain, norepinephrine goes up to help increase blood pressure to force blood flow into the brain.

If one has excessive salt loss, anemia, dehydration and thus low blood pressure, norepinephrine goes up to maintain blood pressure.

etc.

Note that except for the stimulants (including Wellbutrin), practically all psychiatric medications reduce norepinephrine as one of the central targets of treatment.

Blood pressure medications – except for the diuretics – block or reduce norepinephrine directly or indirectly.

Stress-reduction behavioral interventions, excercise, yoga, meditation, all help reduce norepinephrine – the primary stress signal.

@BlackJack 160 wrote:

WOuld low sodium, ATCH, renin, etc, indicate high norepineprhine.

i have excessive precum, premature ejaculation, stress, anxiet nervouesness, ED….
most of my problems are sexual related.

The sympathetic nervous system-renin-angiotensin-aldosterone system is involved in a positive feedback loop which increases norepinephrine.

High renin from the kidneys results in increased angiotensin II. Angiotensin II increases norepinephrine from the sympathetic nervous system, and increases aldosterone from the adrenal cortex.

Low sodium is a condition which would increase renin, which leads to an increase in norepinephrine.

This is a system which attempts to maintain blood pressure.

One could just use more salt in their diet to help with these issues. Some people are just salt wasters by nature. Your thyroid is not that terrible low. The numbers are getting better, but you have those elevated antibodies which would probably have destroyed your thyroid by now and at this point and time are worthless trying to chase as the damage probably has been done. Your on cortef at 15 mgs a day and this is not even helping such as we tried it as a trial dosage and you have not responded as we have anticipated. Your saliva test where low normal but again you were sitting on the fence with everything. Personally you need to remind people of your past lifestyles of partying and other factors that could have put you in the position you are today. Hashimotos is just a symptom of the cause which was beating your body to the ground, but lack of sleep for lord knows how many years. With your high shbg this is causing your bio T to take a beating even though your numbers are good I still seem to think there are other issue at play going on that need to be addressed .I have not yet been able to pin pointed but the next time you come down we may do hypnosis to get at the underlying cause. We have pretty much ever thing in check and still not right. I personally think that one past party has impacted your neurotransmitters. If you wish to go into detail with this and have Dr M give us a view point of just how much damage this could have caused that is up to you. Due to patient/client relationship I am not going to violate the confidentiality. As with all my clients I ask for permission even if their names are not mentioned their case scenrios could also be in violation of this act. After readings your post I know cymbalta tends to help modulate norephipherine and also serotonin. Next time we test fractional catecholamine may be needed to help rule this out. When using this type of testing what would the diagnostic code which could be used. I know some times when anxiety is listed as diagnostic codes this may not be good to have this on ones records because it can be look down upon in future.

Can norepinephrine be elevated due to slow breakdown; MAO deficiency?

@DrMariano 291 wrote:

Yes. For example, a catechol-o-methyl transferase deficiency may lead to an increase in norepinephrine, contributing to hypertension during pregnancy (Preeclamsia).

Would sam-e help to modulate neurotransmitters and help to deal with a COMT deficiency?
Isn’t Methylation is the prime mechanism for the COMT enzyme and detoxifcation of the 2,16,4 ohe as well?

@hardasnails1973 297 wrote:

Would the appropriate Icd-9 code applied to fractional catecholamine fractional be anxiety unspecified?

It depends on what the insurance company would accept as an acceptable code. If anxiety disorder unspecified is one reason to test for it, then so be it.