@hardasnails1973 35 wrote:

Due to the fact that I finally had every thing dialed in perfectly. I got my PSA test back and it had gone up from .4 to 1.4. This scared the shit out of me. All I did was to go from 25 mgs to 50 mgs of dhea a day. When I had my 2/16 hydroxy ratio checked . I had to take up to 8 pills of dim pro a day just to get it with in normal range >2 and that was on 25 mgs of dhea. Since I saw this psa rise. I had been on TRT and adex at .25 EOD and everything was perfect. So I decided to switch to 7 keto and 500 mgs trans100% resveratrol. Knowing that dhea was responsible for estroidial issues on TRT swithcing to 7 keto would have reduce the estrodial tremendously. With this in mind I stopped the adex to compensate for it. With in a few days of stopping dhea and swithcing over to 7 keto and rev I notice incredible fatigue and joint pains, bloating and brain fog, as well as increased muscle spasms. Could the change in actaully be driving my estrodial levels down so low that it could be giving me these low estrodial symptoms. Alot of the symptoms also seem to be hypothryoid/adrenal related as the drop in e2 could be increasing thyroid ans over taxing the adrenals.

That is a lot and an expensive amount of DIM to take.

I also would consider using Iodine instead since it can also improve the estrogen 2/16 hydroxy ratio. And it is a lot less expensive. And it can promote prostate cancer cell death (apoptosis).

7-Keto DHEA increases immune system activity more than DHEA. 7-Keto, for example, increases IL-2, a pro-inflammatory signal of the immune system (also called a cytokine), more than DHEA.

Pro-inflammatory signals of the immune system (i.e. pro-inflammatory cytokines), can trigger a programmed sickness behavior, called a defensive posture, in mammals. This includes a nervous system mediated loss of energy, impaired thinking, loss of interest in activities, social isolation. This is similar to – if not is – a depressed state. Pro-inflammatory signals promote inflammatory processes as part of the immune response. This, however, can lead to inflammatory conditions such as joint pains, muscle pains, allergies, asthma, certain gastrointestinal disturbances (particularly since the intestines have the highest concentration and amount of white blood cells and other immune system cells in the entire body).

Because of the complexity of reproductive hormone actions and interactions, I would be careful to consider the actual condition before leaping to the conclusion that it is a change in estrogen, thyroid or adrenal signaling or function that has caused the problem. Further history and exam is useful. It is useful to consider more lab measurements to help determine what is going on.