@hardasnails1973 38 wrote:

Dr M,
Has specifically does low ferritin affect the thyroid ?
All articles say it effects the active t3 binding, but they do not explain does this mean t-3 actually doing its job at the receptor or the conversion of t4 to t3.
There is speculation that with low ferritin that thyroid can not be activated at the tissue level. Is this really true because I thought cortisol was responsible for this function. Reason being is that I have ferritin of 40 and my hair keeps falling out. I have had low ceruloplasm and copper serum for 5 years now but no one can give me an explanation to why this is. I even supplemented thinking I was low 5 mgs a day reducing zinc down to 30 mgs a day and retested in 2 months. While taking the supplement up to night before the test it still tested low. How can this be..With out ceruloplasm iron does not get transported to the tissue as indicated on alot of my functional test as well as hair analysis copper, iron, molybednum were all low and have been for years. I;m just confused. I have alot of signs of wilsons disease but can not get an accurate diagnosis.

Thyroid is an intercellular signal. It is a signal produced by the thyroid gland which travels to other cells in the body, where it triggers changes in cellular metabolism, which results in an increase in metabolism and energy production and thermogenesis (heat production). These changes include growth in the size and number of mitochondria.

Iron works at the cellular metabolic level/nutrient level. For example, iron is part of the structure of numerous enzymes involved in energy production. It is part of the cytochrome enzymes which serve as electron carriers in the synthesis of ATP in mitochondria. It is part of the structure of enzymes such as NADH dehydrogenase, Succinate Dehydrogenase, and Aconitase, which are central to the function of the Citric Acid Cycle in mitochondria. The citric acid cycle is where the body processes carbohydrates, pyruvate, acetyl-CoA, etc. into ATP.

Without iron, the metabolic actions triggered by thyroid hormone grind to a halt. Thyroid hormone doesn’t work without enough iron. Thyroid hormone replacement does not work well without adequate iron levels – best measured by serum Ferritin levels.

Cheers.

Im sure low iron/ferritin would cause thyroid issues.

Im about to have a complete thyroid panel as well as iron studies to see where i am at with both as well.